The toxin acts after incubation period (3-14) days) at several sites within central nervous system, including peripheral motor end plates, spinal cord, brain and sympathetic nervous system. The typical clinical manifestations of tetanus are caused when tetanus toxin interferes with release of neurotrasmitters, blocking inhibitor impulses.

Blockade of spinal inhibition is produced when toxin acts at synapse of interneurons of inhibitory pathways and motor neurons. General muscle rigidity arises from uninhibited afferent stimuli entering central nervous system from periphery. The effect of toxin on brain is controversial; direct inoculation can cause seizures.

One of many complications from tetanus is respiratory failure secondary to spasms, obstruction by secretions, exhaustion and pulmonary aspiration. Cardiovascular complications thought to be due to hyperactivity of sympathetic nervous system include tachycardia, with heart rates over 180 beats per minute, severe vasoconstriction and hypertension. Autonomic dysfunction is seen as increased basal sympathetic activity and episodes of sympathetic over activity. (SOA).

-Am I certain that I never want to have children in future?

-Although success rate is very high, it’s not a 100% that this will work for me.

-I have discussed my choice to have vasectomy surgery with my wife/partner.

-This is a very quick and relatively safe surgery, however like any operation there are dangers and risk of complications.

-I assume I will never have children, but just incase I change my mind in future do I want to go to a sperm bank prior to surgery and have my sperm preserved.

-I have done all research I can think of to make sure I have all facts I need to make an informed decision.

-I have consulted my doctor and asked all questions I could think of and I’m confident that I want to have procedure done.

This is only a short article about vasectomies. The bottom line is it’s your life and doing as much investigating and research as possible will help you to make sure you make right choice. Don’t be shy about making a long list of questions to ask your doctor. Sometimes people are intimidated by there doctor’s because you don’t have vast knowledge he/she has. If a doctor is evasive or try’s to blow off your questions than be persistent if you still can’t get your questions answered then find another surgeon.