1. Always play with money you can afford to lose.
Let's face it. No matter what tips and strategies I give you on this page, house still has edge on any slot game you play. So best way to play smart is to play with entertainment money, fun money. DON'T play with rent money. Scared money always loses; whether or not you're superstitious.
2. Always play max bet.
If you don't play max bet, then you reduce your payout percentage considerably, because biggest jackpots always require max bet in order to win. And biggest jackpot is calculated into your payout percentage. You want your payout percentage to be high, and in order for that to happen, you MUST play max bet. If you can't afford max bet, then play lower limits.
3. Understand rules and payouts of machine before you play.
My winning slot strategies are always aimed at maximizing entertainment value of your slots play. To me, that's just being realistic. And best way to enjoy any game, and especially a gambling game, is to understand what's going on.
4. Set win goals.
This one might be controversial to some people, but fact is that if you're up for a session, you might as well quit when you've hit your win goal so you can feel good about it. Go see a show, enjoy a nice meal, or catch some of tourist attractions before you play all your winnings back. People who win quit when they're ahead.