Mechanism of Action of AlprazolamWritten by Kathy Jones
Generic Xanax is a tranquilizer used in short-term relief of symptoms of anxiety or treatment of anxiety disorders. Anxiety disorder is marked by unrealistic worry or excessive fears and concerns. Generic Xanax is also used in treatment of panic disorder, which appears as unexpected panic attacks and may be accompanied by a fear of open spaces called agoraphobia. Only your doctor can diagnose panic disorder and best advise you about treatment. Anxiety associated with depression is also responsive to Xanax. Some doctors prescribe Generic Xanax to treat alcohol withdrawal, fear of open spaces and strangers, depression, irritable bowel syndrome, and premenstrual syndrome. Alprazolam is a Benzodiazepine with a complex chemical / pharmaceutical structure, having a triazolo 1,4 benzodiazepine analog unit. Benzodiazepines are sedative type anxiety medication products. They help in short-term relief of mild to moderate anxiety attacks, panic disorders and nervous tension. All benzodiazepine cause dose-related suppression of central nervous system, varying from slight impairment to hypnosis Alprazolam, naturally, is a white crystalline powder, soluble in alcohol, chloroform, sparingly soluble in acetone, slightly soluble in ethyl acetate and virtually not soluble in water at normal pH levels. Xanax is a branded product of Alprazolam (Generic Xanax) family with active ingredients of alprazolam chemical groups.Each Xanax bar or tablet contains suitable amount of alprazolam and inactive ingredients like pharmaceutical grade corn/maize starch, cellulose, decussate sodium, lactose, magnesium stearate, silicon dioxide, sodium benzoate and small amounts of edible colors for coloration. Generic Xanax / Alprazolam range anxiety medication products are fairly safe for rapidly reducing symptoms of anxiety attacks. They need not be taken on an ongoing basis for a long time in order to be effective. Alprazolam is superior Benzodiazepine Alprazolam is often preferable to other available benzodiazepine based products, such as chlordiazepoxide, clorazepate and prazepam because it has a relatively shorter half-life in human system. Alprazolam does not have any active metabolite derivative that can lead to accumulation in human system, particularly in elderly patients. That’s reason generic Xanax / Alprazolam is favored class among other benzodiazepine. Generic Xanax-Alprazolam when orally administered is immediately absorbed in human physiological system through stomach and small intestine. The liver then metabolizes it. The peak plasma concentrations in human system depend on dosages and active alprazolam groups and occur 1 to 2 hours after administration. The half-life range is 6 to 20 hours following single dose administration. With multiple doses, given 3 times daily, steady state is reached within 7 days. When generic xanax is absorbed in human system, CNS (Central Nervous System) agents of 1,4 benzodiazepine class presumably exert their effects by binding at stereo specific receptors at several sites within brain and central nervous system. Mechanism of Action
| | "New Study, Proof That Vitamin E Kills"?Written by DocStuey
Making Sense of New Study... It’s only when many trials were combined into one big meta-analysis("supertrial") that it became evident. There is ample proof that Alpha-Tocopherol can become deadly, NOT Vitamin E!Alpha Tocopherol is Not "Vitamin E" The focal point in understanding an apparent change of heart, a growing rift within Health Community, Nutrition and Supplement Industry, and Risk/Benefit ratio of taking Vitamin E Supplements, is one of deceit perpetuated on population at large. To understand this, you’ll need to realize that supplements commonly labeled "vitamin E", including those used in nineteen clinical trials which were basis of a meta-analysis, underlying newly realized increase in death rate due to high dose supplementation, are mislabeled and misleading. They do not contain "vitamin E", simple fact being, there’s no such thing. Alpha-tocopherol is no more "vitamin E" than folic acid, riboflavin or pyridoxine on their own can be called "vitamin B". As it is with "vitamin B", "vitamin E" is a complex of several member molecules, each having an important role and proper ratio. The Vitamin E Complex is a family of eight molecules, four tocopherols and four tocotrienols. These eight E-complex family members work synergistically, within body to support healthy function of organs, tissues, and provide protection from free radical damage; as well, they support assimilation and utilization of other nutrients. Even "vitamin E" sold as complete "with mixed tocopherols", still delivers only half of E-complex, leaving you missing all four highly beneficial tocotrienols. On top of this, ratios of different tocopherols contained in most "mixed tocopherols" supplements are at best, dangerously unbalanced. These products typically contain an average five times as much alpha-tocopherol as other three tocopherols combined. These such formulations pretty much guarantees that you won’t gain any health benefits from these other vitamin E molecules. It has now become fact based knowledge, that excessive supplementation of alpha-tocopherol depletes your body of other E-complex vitamins, cheating you of their benefits. In fact, when alpha-tocopherol is taken at doses typical of most "vitamin E" supplements, counterbalancing it with proper ratio, or even an equal amount of other E vitamin E complex, isn’t enough to prevent this supplement induced deficiency. The excessive alpha-tocopherol still drives out gamma, leaving your levels around 30% below that of a average, non-supplemented diet. Not only does this lower level of other E-complex molecules in your body, too much alpha-tocopherol can directly counteract some of unique effects of other E vitamin molecules if they exist at all in your diet or supplements. So how much is too much? The “high dose” referred to in trials was (> 400 IU) and results were clear: people taking 400 IU or more of alpha-tocopherol per day, actually increase their risk of death.
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