Bextra and Vioxx Withdrawal Spurs Price Increase Among Rivals

Written by Charles Essmeier


The market for painkillers is huge. People don’t like pain and inflammation, and last year Americans spent nearly $4 billion on just two of them – Vioxx and Bextra. Those two drugs, part of a family of non-steroidal anti-inflammatory drugs known as COX-2 inhibitors, were withdrawn fromrepparttar market recently amid concerns that they can cause heart attacks and strokes. The loss of these two drugs torepparttar 141459 marketplace is huge, as they wererepparttar 141460 two largest sellers in a fairly narrow field. COX-2 inhibitors differ from traditional non-steroidal anti-inflammatory drugs in that they inhibit production ofrepparttar 141461 COX-2 enzyme that causes inflammation but do not interfere with COX-1,repparttar 141462 enzyme that protectsrepparttar 141463 stomach lining. Patients who use these drugs are thought to suffer less from internal discomfort and bleeding than those who took traditional anti-inflammatories, such as naproxen and ibuprofen.

Withrepparttar 141464 withdrawal of these two blockbusters, patients with chronic pain, such as arthritis sufferers, are now going back to older painkillers, such as Mobic, Motrin, and Relafen. Sincerepparttar 141465 more popular Vioxx and Bextra are no longer available, these older drugs are enjoying a resurgence in popularity, and sales are up acrossrepparttar 141466 board. So, it seems, are their prices. A recent study by a popular consumer

Cholesterol- How It Works In Your Body?

Written by Mahesh Bhat


Since those original studies,repparttar risk of heart disease stemming from cholesterol has exploded. In 2002 it was estimated that 107 million American adults now have a blood cholesterol level high enough to require medical advice. Unfortunately,repparttar 141396 numbers keep rising.

As mentioned above, cholesterol in and of itself, is a natural function ofrepparttar 141397 human body. Every living being requires a certain amount of fat to exist. Like everything in nature, it o­nly becomes a problem when there is an imbalance.

The processing of fat begins when it gets absorbed inrepparttar 141398 intestines. From there it heads torepparttar 141399 liver. The fat requires a delivery system torepparttar 141400 rest ofrepparttar 141401 body to be used immediately but also to be stored in fat cells for future use.

In order forrepparttar 141402 fat to enterrepparttar 141403 delivery system, while it is inrepparttar 141404 liver it is split into two different types of fat, cholesterol and triglycerides.

Once this transformation takes place,repparttar 141405 two types of fat (cholesterol and triglycerides) are packed into vehicles for carryingrepparttar 141406 fat torepparttar 141407 fat cells throughoutrepparttar 141408 body usingrepparttar 141409 bloodstream. These vehicles are called lipoproteins.

There are three types of lipoproteins:

1. Very Low Density Lipoproteins (VLDL) 2. Low Density Lipoproteins (LDL) 3. High Density Lipoproteins (HDL)

Under normal circumstances,repparttar 141410 bloodstream does a very efficient job of carryingrepparttar 141411 LDL and HDL Lipoproteins throughoutrepparttar 141412 body.

Cholesterol is a waxy, fat like substance that presents itself naturally in cell walls and membranes everywhere in your body. Your body uses cholesterol to produce many hormones. It also uses it to produce vitamin D andrepparttar 141413 bile acids that help to digest fat.

Where problems arise is when there is an over abundance of cholesterol in your bloodstream. The cholesterol deposited byrepparttar 141414 LDL leads to a narrowing ofrepparttar 141415 blood vessels.

If this occurs,repparttar 141416 excess can be deposited inrepparttar 141417 arteries ofrepparttar 141418 heart which could result in stroke or heart disease. This is called atherosclerosis. This is why LDL is known as “bad cholesterol.”

HDL usually collectsrepparttar 141419 bad cholesterol and takes it back torepparttar 141420 liver. That’s why HDL is known as “good cholesterol.”

Cholesterol is notrepparttar 141421 o­nly cause of heart disease, but it is a contributing factor. Here’s how it works.

Cholesterol can o­nly attach torepparttar 141422 inner lining ofrepparttar 141423 artery if it has been damaged. o­ncerepparttar 141424 lining ofrepparttar 141425 artery is damaged, white blood cells rush torepparttar 141426 site followed by cholesterol, calcium and cellular debris. The muscle cells aroundrepparttar 141427 artery are altered and also accumulate cholesterol.

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