THE ETIOLOGY OF DIABETES MELLITUS

Written by Wong Hon Long


Continued from page 1

The etiology of type II diabetes mellitus (non-insulin- dependent diabetes mellitus, NIDDM) is even less clearly understood. Two factors have been identified:

a) Impaired insulin release-basal secretion of insulin is often normal, butrepparttar rapid release of insulin follows a meal is greatly impaired, resulting in failure of normal handling of a carbohydrate load. In most patients, some level of insulin secretion is maintained, so thatrepparttar 113904 abnormality of glucose metabolism is limited and ketoacidosis is uncommon. In these patients, insulin secretion can be stimulated by drugs such as sulfonylureas. Exogenous insulin is therefore not essential in treatment. It also have been suggested that inheritance of a defective pattern of insulin secretion is responsible forrepparttar 113905 familial tendency of diabetes. The genetic factor is very strong in type II diabetes, with a history of diabetes present in about 50% of first degree relatives.

b) Insulin resistance-a defect inrepparttar 113906 tissue response to insulin is believed to play a major role. This phenomenon is called insulin resistance and is caused by defective insulin receptors onrepparttar 113907 target cells. Insulin resistance occurs in association with obesity and pregnancy. In normal individuals who become obese or pregnant,repparttar 113908 B cells secrete increased amounts of insulin to compensate. Patients who have genetic susceptibility to diabetes cannot compensate because of their inherent defect in insulin secretion. Thus, type II diabetes is frequently precipitated by obesity and pregnancy. In a few patients with extreme insulin resistance, antibodies againstrepparttar 113909 receptors have been demonstrated in plasma. These antibodies are mostly ofrepparttar 113910 IgG class and act againstrepparttar 113911 insulin receptors, causingrepparttar 113912 decreased numbers of insulin receptors and defective binding of insulin to receptors.

Other specific types of diabetes mellitus includes maturity-onset diabetes ofrepparttar 113913 young (MODY), diabetes due to mutant insulin, diabetes due to mutant insulin receptors, diabetes mellitus associated with a mutation of mitochondrial DNA and obese type 2 patients.

( www.medical-explorer.com )

Male, Malaysian


Hair Loss Resources

Written by L. Lysek


Continued from page 1

Many of these sites helprepparttar patient to search for a doctor and some even haverepparttar 113903 facility to directly consult a doctor. If you want to go through hair transplant, you need not visit a doctor personally to understandrepparttar 113904 procedure. Then we have websites such as www.hairtransplantdocs.com, which are turning out to berepparttar 113905 best resources for of hair loss patients. These sites provide you enough information regardingrepparttar 113906 procedure. These sites also give you an opportunity to search and interact with hair transplant doctors. Some of these sites help you to search for hair transplant doctors throughoutrepparttar 113907 world and gather information about them. You can satisfy your doubts by knowingrepparttar 113908 profile ofrepparttar 113909 doctor before interacting directly. You can also go throughrepparttar 113910 questions that other people have posed. This helps you in shedding doubts and fear.

This article may be distributed freely on your website, as long as this entire article, including links and this resource box are unchanged.

Copyright 2005 All Rights Reserved. LTC Publishing http://www.hair-loss-treatment-solution.com



Les Lysek, writer, speaker, marketing master, specializes in infoproduct development. More articles about hair loss at: http://www.hair-loss-treatment-solution.com


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