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So, yes some treatments will work on most outbreaks but there will definitely be a stage of herpes simplex virus immune syndrome that will eventually make most all present day treatments ineffective. Simply meaning more you try to treat outbreaks with various medications sooner you will reach stage where no treatment will help.
You must also keep in mind that your present overall health conditions and other variables may temporarily slow or stop a remedy from working. So it may not always be virus but your present health condition that blocks any remedy from working what is your solution for cold sore outbreaks? If you have simple small split type sore just let it run course. Your body will develop antibodies to overpower virus outbreak which will help keep new outbreaks from happening so repeatedly.
However if you have major Mt Saint Helen's size outbreak then you can try various medications and treatments in hopes that you will hit right one.
A rule of thumb would be not to use remedies that you have recently used in past simply because of likelihood that virus has already become immune to it.
For a list of cold sore medications and home remedies see: http://www.bnbmarketing.net/coldsoreremedies.htm
About the author: Dan Adams is the founder of BnB Associates, Inc. His company has offered natural oxygenated skin and health remedies since 1996. http://www.bnbassociates.us mailto:ceo@bnbmarketing.net