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With that in mind, it would make sense to use a painkiller that can do both of these. Aspirin and NSAIDS (non-steroidal anti-inflammatory drugs), such as ibuprofen and Motrin decrease
prostaglandins. This can result in decreased pain and inflammation, especially if
prostaglandins are
main causes.
However, aspirin and NSAIDS do not directly affect
other pain chemicals and do not affect
pain nerve,
C fiber.
Narcotics, such as Darvon or codeine, have no known effect on either
"pain" bio-chemicals or
pain nerves. Acetaminophen (Tylenol) also has no significant effect on these at usual doses. And in fact,
way acetaminophen works is not actually known.
But we also know we can interrupt
pain impulse away from
injury site, at
spinal cord. If our pain killer could also decrease
release of (or deplete
C fiber of) Substance P,
pain impulse would be blocked at
spinal cord level. Aspirin and NSAIDS have no known effect at this site. Narcotics and tricyclic antidepressants, such as amitriptylene or Elavil, on
other hand, actually can block
release of Substance P and stop transmission at
spinal cord level, but once again have no value in decreasing
levels of
bio-chemicals of pain.
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Jaynne is an instructor at the local community college. She is also a former skipatroller and thus very interested in health issues. Read her latest article right here: