The mesotheleum helps protect organs by producing a special lubricating fluid that allows organs to move around. For example, this fluid makes it easier for lungs to move inside chest during breathing. The mesothelium of chest is called pleura and mesothelium of abdomen is known as peritoneum. The mesothelium of pericardial cavity (the "sac-like" space around heart) is called pericardium

In 1990s, four randomised, double blind trials with large sample sizes (n = 278–802) tested active versus placebo patch (table 1). The Davidson et al trial28 was similar to other studies except it was conducted in four shopping malls. The Hays et al study31 was conducted at five study sites including private offices or storefronts. The study first randomised subjects into one of two trials: (1) a randomised, two group OTC NRT versus OTC placebo trial in which subjects received free patches; or (2) a one group, open label trial in which subjects had to pay for patches. We did not use open label trial in meta-analysis because it did not have a control group.

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