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Glutathione and Mood Disorders

Studies have found that mood stabilizing drug, valproate, used to treat epilepsy and bi-polar disorder, regulates expression of genes that make glutathione-S-transferase (GST).

In addition, chronic treatment with lithium, another commonly prescribed mood stabilizer used in treating manic-depression, also increased levels of GST.

These findings led researchers to conclude that glutathione S-transferase may be a novel target for mood stabilizing drugs. (7)

Alcohol Consumption and Glutathione

Alcohol abuse is known to impair memory and other brain functions and increase brain cell death. A new study in rats has shown that alchol consumption causes fewer new brain cells to form and results in greater cell death. (8)

But rats that were fed alcohol along with Ebselen - a glutathione peroxidase mimic that acts as a free radical scavenger - showed no similar reduction in brain-cell formation and no increase in cell death.

Substances that Boost Glutathione Levels and Protect Brain Cells

Taking glutathione itself as a supplement does not boost cellular glutathione levels, since it breaks down in digestive tract before it reaches cells.

However, intravenous glutathione therapy and glutathione precursors or dietary supplements are effective in boosting intracellular levels of glutathione.

Intravenous Glutathione Injections: Intravenous glutathione injections have been shown to produce amazing and rapid results, in patients with Parkinson's disease. Following even a single dosage of intravenous glutathione, many of symptoms of Parkinson's disease rapidly improve, often in as little as 15 minutes.

Glutathione Precursors: In Alzheimer's study conducted by Welsh GP, Andrew McCaddon, adding glutathione precursor, N-acetyl-cysteine (NAC) to a protocol that lowered homocysteine levels by simple supplementation with B12 and folate, resulted in prompt, striking, and sustained clinical improvement in nearly all patients. (9)

Cucurmin (turmeric): Studies have shown that Indian curry spice, cucurmin, has neuroprotective effects because of its ability to induce enzyme, hemeoxygenase-1 (HO-1), which protects neurons exposed to oxidant stress. Treatment of brain cells called astrocytes, with curcumin, increases expression of HO-1 protein as well as glutathione S-transferase. (10)

Ebselen: Ebselen is a glutathione peroxidase mimic and potent synthetic antioxidant that acts as a neuroprotective agent and an inhibitor of free-radical induced apoptosis (cell death). It can protect brain cells from neuro-toxic effects of alcohol consumption. (8)

Undenatured Whey Protein: Undenatured whey protein provides glutathione precursors, has been shown to raise intracellular glutathione levels in clinical trials, and has anecdotally been reported to improve symptoms of Parkinson's disease.

References: 1. Journal of Neurochemistry, Vol. 88, No. 3, 2004 513-531 2. Journal of Neurochemistry, Vol. 87, No. 6, 2003 1527-1534 3. Researchers Find Brain Cells Die Differently in Males and Females; Pediatric Academic Societies Press release; 21-Apr-2004 4. Human Molecular Genetics, 2003, Vol. 12, No. 24 3259-3267 5. The Journal of Cell Biology, Volume 164, Number 1, 123-131; 5 January 2004 6. Biol Psychiatry. 2003 Feb;53(3):254-60 7. Journal of Neurochemistry, Vol. 88, No. 6, 2004 1477-1484 8. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7919-24. Epub 2003 Jun 05. 9. Am J Geriatr Psychiatry. 2003 Mar-Apr;11(2):246-9 10. Can Curry Protect Against Alzheimer's?; American Physiological Society (APS) Press Release; 16-Apr-2004