Creatine: More than a sports nutrition supplement

Written by Will Brink


Continued from page 1

More recent studies, in vitro and in vivo in animals, have found creatine to be highly neuroprotective against other neurotoxic agents such as N-methyl-D-aspartate (NMDA) and malonate.4 Another study found that feeding rats creatine helped protect them against tetrahydropyridine (MPTP), which produces parkinsonism in animals through impaired energy production.

The results were impressive enough for these researchers to conclude, "These results further implicate metabolic dysfunction in MPTP neurotoxicity and suggest a novel therapeutic approach, which may have applicability in Parkinson's disease."5 Other studies have found creatine protected neurons from ischemic (low oxygen) damage as is often seen after strokes or injuries.6

Yet more studies have found creatine may play a therapeutic and or protective role in Huntington's disease7, 8 as well as ALS (amyotrophic lateral sclerosis).9 This study found that "? oral administration of creatine produced a dose-dependent improvement in motor performance and extended survival in G93A transgenic mice, and it protected mice from loss of both motor neurons and substantia nigra neurons at 120 days of age.

Creatine administration protected G93A transgenic mice from increases in biochemical indices of oxidative damage. Therefore, creatine administration may be a new therapeutic strategy for ALS." Amazingly, this is onlyrepparttar tip ofrepparttar 140032 iceberg showing creatine may have therapeutic uses for a wide range of neurological disease as well as injuries torepparttar 140033 brain.

One researcher who has looked atrepparttar 140034 effects of creatine commented, "This food supplement may provide clues torepparttar 140035 mechanisms responsible for neuronal loss after traumatic brain injury and may find use as a neuroprotective agent against acute and delayed neurodegenerative processes."

Creatine and heart function

Because it is known that heart cells are dependent on adequate levels of ATP to function properly, and that cardiac creatine levels are depressed in chronic heart failure, researchers have looked at supplemental creatine to improve heart function and overall symptomology in certain forms of heart disease.

It is well known that people suffering from chronic heart failure have limited endurance, strength and tire easily, which greatly limits their ability to function in everyday life. Using a double blind, placebo-controlled design, 17 patients aged 43 to 70 years with an ejection fraction <40 were supplemented with 20 grams of creatine daily for 10 days.

Before and after creatine supplementation,repparttar 140036 researchers looked at:

1) Ejection fraction ofrepparttar 140037 heart (blood present inrepparttar 140038 ventricle atrepparttar 140039 end of diastole and expelled duringrepparttar 140040 contraction ofrepparttar 140041 heart)

2) 1-legged knee extensor (which tests strength)

3) Exercise performance onrepparttar 140042 cycle ergometer (which tests endurance)

Biopsies were also taken from muscle to determine if there was an increase in energy-producing compounds (i.e., creatine and creatine phosphate). Interestingly, but not surprisingly,repparttar 140043 ejection fraction at rest and duringrepparttar 140044 exercise phase did not increase.

However,repparttar 140045 biopsies revealed a considerable increase in tissue levels of creatine and creatine phosphate inrepparttar 140046 patients gettingrepparttar 140047 supplemental creatine. More importantly, patients gettingrepparttar 140048 creatine had increases in strength and peak torque (21%, P < 0.05) and endurance (10%, P < 0.05).

Both peak torque and 1-legged performance increased linearly with increased skeletal muscle phosphocreatine (P < 0.05). After just one week of creatine supplementation,repparttar 140049 researchers concluded: "Supplementation to patients with chronic heart failure did not increase ejection fraction but increased skeletal muscle energy-rich phosphagens and performance as regards both strength and endurance.

This new therapeutic approach merits further attention."10

Another study looked atrepparttar 140050 effects of creatine supplementation on endurance and muscle metabolism in people with congestive heart failure.11 In particularrepparttar 140051 researchers looked at levels of ammonia and lactate, two important indicators of muscle performance under stress.

Lactate and ammonia levels rise as intensity increases during exercise and higher levels are associated with fatigue.

High-level athletes have lower levels of lactate and ammonia during a given exercise than non-athletes, asrepparttar 140052 athletes' metabolism is better at dealing with these metabolites of exertion, allowing them to perform better.

This study found that patients with congestive heart failure given 20 grams of creatine per day had greater strength and endurance (measured as handgrip exercise at 25%, 50% and 75% of maximum voluntary contraction or until exhaustion) and had lower levels of lactate and ammonia thanrepparttar 140053 placebo group.

This shows that creatine supplementation in chronic heart failure augments skeletal muscle endurance and attenuatesrepparttar 140054 abnormal skeletal muscle metabolic response to exercise.

It is important to note thatrepparttar 140055 whole-body lack of essential high energy compounds (e.g. ATP, creatine, creatine phosphate, etc.) in people with chronic congestive heart failure is not a matter of simple malnutrition, but appears to be a metabolic derangement in skeletal muscle and other tissues.

Supplementing with high energy precursors such as creatine monohydrate appears to be a highly effective, low cost approach to helping these patients live more functional lives, and perhaps extend their life spans.

Conclusion

Creatine is quickly becoming one ofrepparttar 140056 most well researched and promising supplements for a wide range of diseases. It may have additional uses for pathologies where a lack of high energy compounds and general muscle weakness exist, such as fibromyalgia.

People with fibromyalgia have lower levels of creatine phosphate and ATP levels compared to controls.13 Some studies also suggest it helps withrepparttar 140057 strength and endurance of healthy but aging people as well.

Though additional research is needed, there is a substantial body of research showing creatine is an effective and safe supplement for a wide range of pathologies and may berepparttar 140058 next big find in anti-aging nutrients.

Althoughrepparttar 140059 doses used in some studies were quite high, recent studies suggest lower doses are just as effective for increasingrepparttar 140060 overall creatine phosphate pool inrepparttar 140061 body.

Two to three grams per day appears adequate for healthy people to increase their tissue levels of creatine phosphate. People withrepparttar 140062 aforementioned pathologies may benefit from higher intakes, inrepparttar 140063 5-to-10 grams per day range.

Download Your FREE Indepth Report On Creatine's Usage in Sports , Health and Anti Aging Creatine Report From Sports Nutrition Expert Will Brink here: http://www.creatine-report.com And see Will's other websites here: http://www.dietsupplementsreview.com http://www.musclebuildingguide.com


Eating Habits And Disorders

Written by James Harison


Continued from page 1

1. Eating without hunger 2. Embracement of weight 3. Engaged in continual diet

Symptoms of Anorexia Nervosa:

1. Fear of becoming fat/obese 2. Social withdrawal, perfectionism. 3. Loss of menstrual cycle 4. Body weight below normal weight

Tips for Healthy Eating:

1. Donít skip meal: Plan your daily meal and snacks. For healthy eating habit, we should have 3 meals and 2 snacks every day.

2. Learn simple way to prepare food: Try to learn various simple way of preparing food for yourself. Try dried herbs (basil, parsley) and spices (chili powder, lemon pepper) instead of adding topping link butter and gravy.

3. Avoid eating more sugar: Sugar drinks contain more energy inrepparttar form of calories and these drinks do not have other vitamins and protein which body needs. So avoid such type of drinks.

4. Pay attention to your eating while having meal: Listen to our body while you are having meal. Stop when you feel satiated. This will help your body to balancerepparttar 139982 energy.

This article is submitted by James Harison, Editor to slimtour.com. Please Visit the website http://www.slimtour.com for more solutions about Weight Loss.


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