Growth may begin as a small lump just under areola (colored skin around nipple). During growth, this tissue is often tender.

What causes gynecomastia? Gynecomastia is usually secondary as a result of hormonal imbalances between testosterone and estrogen often occurs during puberty.

But gynecomastia can also be result of an underlying medical problem, or can be induced by drugs such as Risperdal®.

Treatments for gynecomastia Treatment may be required if your child has very large breast development and it is shrinking. In addition, surgery may be required in cases where breast growth is causing a stress anxiety in your child. When male breast growth does not stop within three years, it may not go away on its own. In those cases, you should consult a Plastic Surgeon.

Bextra is approved to treat pain from arthritis and, like Merck & Co.'s Vioxx, is a COX-2 inhibitor. A recent trial showed Vioxx doubled risk of heart attack and stroke in arthritis patients who took drug for more than 18 months.

The Vioxx withdrawal has cast a cloud over entire class of COX-2 inhibitors, which includes Bextra, Celebrex and an experimental drug from Novartis AG called Prexige.

However, Pfizer said that following Vioxx withdrawal it re-examined its clinical data base of 8,000 patients with rheumatoid arthritis and osteoarthritis and found no increased risk of dangerous heart events in patients taking Bextra for up to a year. The company also found no increased risk in a trial of patients taking Bextra in a general surgery setting.

Doctors said it is too early to quantify potential risk of Bextra or of Pfizer's other COX-2 inhibitor Celebrex as neither have tested for long enough. Pfizer said it is conducting longer term trials in arthritis patients.

The coronary bypass trials are ones that Dr. Eric Topol of Cleveland Clinic Foundation and an early and outspoken critic of Vioxx, said he finds concerning as they show a cluster of heart attacks and strokes. But he said danger signal does not appear to be as strong as it was with Vioxx.

"Celebrex and Bextra do appear safer than Vioxx but whether they are really safe, especially in patients with heart risk, that's an open question," Topol said.

Pfizer has updated label on several occasions since it was approved in 2001 to reflect risk of Stevens Johnson syndrome, a form of allergic reaction often caused by certain types of drug. Symptoms usually begin as a blistering of mouth and lips, spreading to throat, tongue and other parts of body. The blisters sometimes become so extensive as to be fatal. The company also updated its warning that Bextra can cause a rare, but sometimes fatal, skin disorder called Stevens-Johnson syndrome to note that cases of condition are being seen more often with Bextra than with other drugs in same class.

Bextra is approved to treat pain from arthritis and, like Merck & Co.'s Vioxx, is a COX-2 inhibitor. A recent trial showed Vioxx doubled risk of heart attack and stroke in arthritis patients who took drug for more than 18 months.

The Vioxx withdrawal has cast a cloud over entire class of COX-2 inhibitors, which includes Bextra, Celebrex and an experimental drug from Novartis AG called Prexige.

However, Pfizer said that following Vioxx withdrawal it re-examined its clinical data base of 8,000 patients with rheumatoid arthritis and osteoarthritis and found no increased risk of dangerous heart events in patients taking Bextra for up to a year. The company also found no increased risk in a trial of patients taking Bextra in a general surgery setting.

Doctors said it is too early to quantify potential risk of Bextra or of Pfizer's other COX-2 inhibitor Celebrex as neither have tested for long enough. Pfizer said it is conducting longer term trials in arthritis patients.

The coronary bypass trials are ones that Dr. Eric Topol of Cleveland Clinic Foundation and an early and outspoken critic of Vioxx, said he finds concerning as they show a cluster of heart attacks and strokes. But he said danger signal does not appear to be as strong as it was with Vioxx.

"Celebrex and Bextra do appear safer than Vioxx but whether they are really safe, especially in patients with heart risk, that's an open question," Topol said.

Pfizer has updated label on several occasions since it was approved in 2001 to reflect risk of Stevens Johnson syndrome, a form of allergic reaction often caused by certain types of drug. Symptoms usually begin as a blistering of mouth and lips, spreading to throat, tongue and other parts of body. The blisters sometimes become so extensive as to be fatal.