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Itching and pain in side of mole make you suspicious as well.

History of melanoma in Family should also raise suspicions.

Some skin problems look like melanoma, but are actually harmless. Anyway, do not gamble with them. Even experienced physician can not always tell if lesion is malignant or not. It is better to be safe then sorry and check troubling changes soon.

Some rare types of melanoma exist. Because even obvious melanomas are not always diagnosed on time, unusual types becomes much more deadlier. Often doctor sees them too late.

Melanoma under nails. Melanoma of mucous membranes. (Mouth, nose or guts) Amelanotic melanoma - this one is not even colored.

The treatment will be excision with margins and biopsy, but most important of course is to catch melanoma Know that treatment depends on thickness of tumor and presence of distant metastasis.

Surgeon or dermatologist cuts off melanoma. Then, Pathologist (doctor specializing in lab diagnostics) looks sample under microscope.

He classifies tumor. The grade of tumor gives clue to chances of your survival.

There are several classifications

Breslow classification measure penetration of lesion into skin by millimeters. Know that > 0.75 mm is already dangerous, but > 4 mm is wacking.

What is 4 mm. It is nothing. Right? Take a ruler and check how 1 mm looks and how 4 mm looks.

So this is why it is important to catch melanoma early.

There is also Clarks classification that measures penetration of melanoma into skin and other layers.

TNM classification standardizes grading.

You can not know grade unless you excise and measure melanoma penetration under microscope. It is not a do-it-yourself project. Surgeon and pathologist will do it.

The time of evolvement 1-2 years.

The frequency of melanoma is increasing. It might be because of more people get sun damage. Also other reasons may play role.

Treatment of melanoma includes surgical removal, chemotherapy, immunotherapy, radiation therapy.

Keywords: Melanoma, mole, nevus, dermatology, pathology, surgeon

Aleksandr Kavokin MD/PhD, Phila http://www.kavokin.com Aleksandr Kavokin, MD1994 Russia,PhD1997 Russia - Immunology and Allergy, postdoc at Cancer Center at Med U of South Carolina, postdoc at Yale - Cardiology, Molecular Medicine. http://www.kavokin.com http://www.kavokin.uni.cc http://www.geocities.com/aging_rejuvenation/ http://www.appendicitis.uni.cc/ http://www.geocities.com/appendicitis_disease/