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Several doctors say they are worried about
possibility of heart attacks because many of
arthritis patients taking
drugs are elderly and have a higher risk of cardiovascular problems to begin with. The current debate centers on whether
higher heart attack rate found in patients taking Vioxx is a result of
drug’s actually causing damage in some patients or to an absence of
heart-protecting benefits that Naproxen may have.
“Naproxen had a similar anti-platelet effect to aspirin,” said Dr. Eve E. Slater, senior vice president of external policy for Merck’s research labs, “and those people had fewer heart attacks.”
Neither Vioxx nor Celebrex has been shown to have
same heart-protecting benefit.
Slater also said that Stover’s report was flawed and biased in favor of Pharmacia. But regulators and some doctors say they still worry that there may be more of a problem with Vioxx. And even if Vioxx and Celebrex do not damage
heart,
fact that they do not have
heart-protecting benefits of aspirin reduces
ability of
companies to market them as being significantly safer than other pain relievers. Merck recommended last year that doctors involved in clinical trials of Vioxx consider prescribing low doses of aspirin to patients taking Vioxx if they are at high risk of heart attacks - although low doses of aspirin could increase
risk of ulcers. Ulcers are
main side effect that Vioxx and Celebrex were developed to avoid.
There have been no studies done to determine whether patients have fewer ulcers if they take low doses of aspirin with either Vioxx or Celebrex. In February Dr Maria Lourdes Villalba, at an FDA advisory meeting, stated that Merck had proved Vioxx [Rofecoxib] caused fewer serious ulcers than Naproxen. However, she also state that
potential safety advantage was offset by a higher risk of heart problems,in her opinion. She reported that “Overall, there was no safety superiority of Rofecoxib over Naproxen, mainly due to an excess of serious cardiovascular events”.
Dr Villalba also stated that there had been no studies to prove Merck’s claim that Naproxen worked like aspirin in decreasing heart attacks. The FDA expressed some concern over
higher rate of heart attacks with Vioxx, stating that this could be caused by
drug’s ability to produce blood clots.
“There is still a tremendous benefit with these drugs” reported Dr Eve Slater of Merck.

Margot B, Writer, Web Developer Margot B has written a book and hundreds of articles, specializing in health and the environment.
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